General Information

  • ID:  hor001371
  • Uniprot ID:  A0A8J5MJP5
  • Protein name:  FMRFamide-related peptide
  • Gene name:  NA
  • Organism:  Homarus americanus (American lobster)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Homarus (genus), Nephropidae (family), Nephropoidea (superfamily), Astacidea (infraorder), Pleocyemata (suborder), Decapoda (order), Eucarida (superorder), Eumalacostraca (subclass), Malacostraca (class), Multicrustacea (superclass), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GYSDRNYLRF
  • Length:  10
  • Propeptide:  MIVAAWVLLTTLTWCCQAHAAPVPPVVAALDPPTDALLPAQSQEDDLFALPEKRLLKYFLPASQAWGGDAYPIGQEGTKRGYSDRNYLRFGRSDTNDYEGEEMPESPEKRNRNFLRFGRDQNRNFLRFGRSGSPMEFATDLQEDVELPVEEKRGAHKNYLRFGRGNRNFLRFGRGDRNFLRFGRSVDRQLSSLSCEDCDEEQKAREFTSTPSPTTIQPLARTKRDVSAVLSDDSIESSVLRQINAHRIKRAAAQNFYIPMAWASELQPEEDGIDVTSFEEPQVAKRFSHDRNFLRFGKRDGSDDYPSSSSSAESPAPVVVVRPVEYPRYVRAPSKNFLRFG
  • Signal peptide:  MIVAAWVLLTTLTWCCQAHA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001371_AF2.pdbhor001371_ESM.pdb

Physical Information

Mass: 145110 Formula: C58H83N17O17
Absent amino acids: ACEHIKMPQTVW Common amino acids: RY
pI: 9.17 Basic residues: 2
Polar residues: 5 Hydrophobic residues: 2
Hydrophobicity: -132 Boman Index: -4004
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 39
Instability Index: 2457 Extinction Coefficient cystines: 2980
Absorbance 280nm: 331.11

Literature

  • PubMed ID:  22860213
  • Title:  Mass Spectral Charting of Neuropeptidomic Expression in the Stomatogastric Ganglion at Multiple Developmental Stages of the Lobster Homarus Americanus